Early initiation of insulin may slow development of type 2 diabetes
The ORIGINALE study is the follow up study to the previous ORIGIN study which investigated the effects of treating patients with type 2 diabetes and those with prediabetes with insulin glargine (Lantus).
The ORIGIN study ran for 6 years and the study’s primary aim was to assess whether treatment of prediabetes and early type 2 diabetes with Lantus was associated with increased or decreased heart risks compared with standard, non-insulin treatment. The ORIGINALE clinical study continued monitoring of the patients for another 2.5 years. Out of the 10,535 participants that had completed the ORIGIN study, 5,869 enrolled for the ORIGINALE study.
The researchers used the study to test whether use of insulin to lower blood glucose levels would slow development of heart disease. The results showed no evidence of either a reduction or increase of heart disease but the ORIGINALE follow up study uncovered a different finding.
The researchers found that of the people with prediabetes, those treated with insulin had a lower likelihood of developing type 2 diabetes. In the insulin treated group, 38% of participants with prediabetes developed type 2 diabetes, compared with 42% in the standard care group. When the researchers included possible cases of type 2 diabetes as …read more
Source:: News from Diabetes.co.uk